Long-term Potentiation: Enhancing Neuroscience for 30 YearsTim V. P. Bliss, G. L. Collingridge, Richard G. M. Morris Oxford University Press, 2004 - 398 páginas In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actual neural mechanism used by the brain to store information?This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.Advance praise for Long Term Potentiation: 'This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field.' Colin Blakemore, University of OxfordReadership: Neuroscientists from postgraduate level upwards |
Contenido
III | 3 |
IV | 9 |
V | 17 |
VI | 23 |
VII | 31 |
VIII | 41 |
X | 53 |
XI | 65 |
XXI | 197 |
XXII | 211 |
XXIII | 229 |
XXIV | 235 |
XXV | 249 |
XXVI | 263 |
XXVII | 277 |
XXIX | 301 |
XII | 79 |
XIII | 95 |
XIV | 111 |
XVI | 133 |
XVII | 141 |
XVIII | 159 |
XIX | 175 |
XX | 185 |
XXX | 315 |
XXXI | 329 |
XXXII | 349 |
XXXIII | 357 |
XXXIV | 371 |
393 | |
Términos y frases comunes
activity-dependent AMPA receptors AMPAR amplitude animals Aplysia area CA1 Aẞ b-APs B-catenin basal behavioural Bliss block Brain Res Ca2+ cadherin CaMKII Cdk5 changes channels CNQX Collingridge cortex CREB dendritic dendritic spines dentate gyrus depolarization electrode enhancement EPSC EPSP excitatory experiments expression function fusion pore gene GluR1 GluR2 glutamate receptors hippocampal neurons hippocampal slices impairment increase induction of LTP inhibition input interaction kainate receptors Kandel Kullmann learning and memory Lømo Lond long-lasting long-term depression long-term potentiation LTP induction Lynch Malenka Malinow McNaughton mechanisms mediated mice modules molecular Morris mossy fibre LTP mutant N-methyl-D-aspartate Natl Acad Nature Neurosci neural Neurosci Nicoll NMDA receptor-mediated NMDAR pathway perforant path phosphorylation Physiol place fields postsynaptic presynaptic protein kinase pyramidal cells quantal regulation release role roscovitine signal silent synapses spatial spines stimulation studies subunit synaptic activation synaptic plasticity synaptic responses synaptic transmission tetanus transgenic vitro vivo
Referencias a este libro
Biology of Freedom: Neural Plasticity, Experience, and the Unconscious François Ansermet,Pierre Magistretti Sin vista previa disponible - 2007 |
A cada cual su cerebro: Plasticidad neuronal e inconsciente François Ansermet,Pierre Magistretti Sin vista previa disponible - 2006 |