Judged, then, merely by the effects of the operation upon the disease, there can be no doubt of the propriety of removing even large Rodent Cancers of the face by the combined method of incisions and caustics. But when the cranium is involved, and so formidable a result may ensue from the action of the caustic as an epileptiform attack, it is open to question whether it is proper to interfere. The liability to this occurrence is, however, not universal, and the severity of it in those cases in which it has taken place is uncertain. In no case is the patient the worse for the attack, and most commonly it is slight and transitory. Even when, without a previous incision, the zinc is laid upon the diseased and pulsating dura mater, the subsequent fit is not usually more severe or continued than when the application is made to the cranium. In Mr. De Morgan's case, already alluded to, it was, however, extreme in its severity, though the patient eventually recovered from it, left town in a state of comfort, and was afterwards able to go out shooting. Considering the alternative of abandoning these cases without treatment and the satisfactory result when it has succeeded, there is reason to conclude that the treatment is applicable in all persons who are not already reduced, by the long duration and great extent of the disease, to a condition of hopeless general feebleness. A perusal of the following cases will show that the exhaustion of the patient may be very decided indeed, before the attempt to remove the disease becomes improper. Notwithstanding hæmorrhage during the operation and the subsequent use of the cautery and the chloride of zinc, the patients usually pass a good night, and the next morning are at ease, without depression, and ready for food. The absence of shock, after these operations, is very striking, even in cases in which I had previously doubted the propriety of operating at all. When the operation is over, the process of healing goes on rapidly, being facilitated by the high vitality of the face, and in some situations by the number of points from which cicatrisation starts. On the side of the head, on the contrary, there appears to be a mechanical obstacle, in the firmness of the skull, to the complete healing of a large sore. APPENDIX OF CASES. Removal of the CASE I. Rodent Cancer of the face, extending into the orbit, and destroying the right eye. disease. Recovery. MARY H., aged 70, was admitted, under my care, into one of the Cancer Wards of the Middlesex Hospital, Dec. 16, 1861. She was thin, but in good general health. She presented a deep ulcerated excavation between the globe of the eye and the bones at the inner side of the right orbit. The lids were detached by the ulceration from their internal connections and partly destroyed. What remained of them was fixed in the solid outer wall of the ulcer. The eye was shrunken and sightless, having apparently been perforated through the sclerotic by the ulcer. The margins of the ulcer reached the upper and nearly the lower edges of the orbit, and terminated about the mesial line upon the bony nasal ridge. From the level of its edge, the central chasm had a depth of nearly an inch; its breadth was half as much, and it passed backward close to the lachrymal and adjoining bones; none of which, however, were bare. The disease presented the ordinary characters of |