Fish Physiology : Zebrafish
This cutting-edge resource includes up-to-date information on zebrafish physiology and the tools used to study it, not only as a model species for studies of other vertebrates but with application for studies of human disease and aquatic toxicology. The utility of zebrafish for physiological research is based on several key features including i) a ""fully"" sequenced genome, ii) rapid (3̃ month) generation times), iii) their capacity to produce large numbers of externally fertilized eggs, iv) optical transparency of embryos and larvae, and v) the applicability of reverse and forward genetics t
Fish physiology, v. 29
1 online resource (482 pages).
9780080961378, 0080961371
1049974907
FRONT COVER; ZEBRAFISH; COPYRIGHT PAGE; CONTENTS; CONTRIBUTORS; PREFACE; Chapter 1. Genetic Tools; 1. Introduction; 2. Forward Genetics: From Large Screens to Targeted Screens; 3. Reverse Genetics: Morpholino Knockdowns; 4. Reverse Genetics: TILLING; 5. Reverse Genetics: Zinc Finger Nucleases; 6. Gain of Function: Targeted Misexpression of Genes; 7. Genetic Ablation of Specific Cell Population; 8. Concluding Remarks; Chapter 2. Organization and Physiology of the Zebrafish Nervous System; 1. Introduction; 2. Nervous System Development and General Organization. 3. General Organization of the Zebrafish Nervous System, Subdivisions and Main Functions4. The Peripheral Nervous System; 5. Sensory Systems; 6. Motor Systems and Integrative Centers; 7. Monoaminergic and Related Regulatory Systems; 8. Emotions and Cognition; 9. Nervous System Plasticity; Chapter 3. Zebrafish Vision: Structure and Function of the Zebrafish Visual System; 1. Visual Ecology; 2. Structure of the Visual System; 3. Retinal Projections; 4. Optic Tectum; 5. Visual Behavior; 6. Complex Visual Behavior; 7. Concluding Remarks; Chapter 4. The Zebrafish Inner Ear; 1. Introduction. 2. Development of the Inner Ear3. Generation and Homeostasis of Endolymph in the Zebrafish Inner Ear; 4. Zebrafish Sensory Hair Cells; 5. Mechanotransduction; 6. Neural Activity; 7. Otoliths; 8. Adult Hearing; 9. Concluding Remarks; Chapter 5. Endocrinology of Zebrafish: A Small Fish with a Large Gene Pool; 1. Introduction; 2. Reproduction; 3. Stress: The Cortisol Stress Axis; 4. Growth; 5. Thyroidal Regulation; 6. Energy Homeostasis: Food Intake and Metabolism; 7. Osmoregulation; 8. Summary; Chapter 6. Developmental Physiology of the Zebrafish Cardiovascular System. 1. Cardiovascular Disease: Models Wanted2. Current Models for Cardiovascular System Studies; 3. Filling a Niche with Zebrafish; 4. Unique Advantages of the Zebrafish for Cardiovascular Studies; 5. Vertebrate Cardiac Development; 6. Origin and Lineage of Cells in the Cardiovascular System; 7. Zebrafish Genetics and Development of the Cardiovascular System; 8. Genetic Infrastructure and Tools for Zebrafish Studies; 9. Zebrafish Cardiovascular Mutants; 10. Mutants Affecting Rate, Rhythm and Contractile Properties of the Heart; 11. Relationship Between Cardiovascular Function and Form. 12. Endothelial Cell Specification and Differentiation13. Specification of Artery and Vein; 14. Cell Migration of Angioblasts and Vascular Patterning; 15. Angiogenesis of the Intersegmental Vessels; 16. Lumenization of Vessels; 17. Vascular Stabilization, Mural Cells, and Extracellular Matrix; 18. Angiogenesis of Organs; 19. Chemical Biology Approaches to Study Cardiovascular Biology; 20. Forces that Influence Cardiovascular Development; 21. Endothelial Cell Survival; 22. Zebrafish Models for Vascular Anomalies; 23. Tools for the Study of Cardiovascular Physiology; 24. Vessel Regeneration
25. Cardiac Regeneration